In December 1997, Friedel signed with Liverpool. On February 28th, 1998, at age 26, he made his Premier League debut for the Reds against Aston Villa and by the following season Friedel was named Liverpool’s starting goalkeeper. Although he performed well for Liverpool, the team was inconsistent and following the hiring of Gérard Houllier as the manager, the club signed Sander Westervel as its No. 1 goalkeeper.
Friedel decided his opportunities at Anfield would be limited and in 2000 he signed with the Blackburn Rovers. He finished with 31 appearances for the Anfield club.